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Trials
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer

trialsTrialActive

Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer

A phase 1/2 trial of LEE011 in advanced solid tumours, run by Novartis Pharmaceuticals, active and no longer recruiting.

Overview Connected3

Overview

Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer is a phase 1/2 interventional study registered as NCT01872260 by Novartis Pharmaceuticals, with 255 participants enrolled, started 2013-10-22 and due to reach its primary completion in 2027-02-26. Interventions recorded: LEE011, Letrozole and BYL719.

Setting

A Phase Ib/II, Multicenter Study of the Combination of LEE011 and BYL719 With Letrozole in Adult Patients With Advanced ER+ Breast Cancer

Phase

Phase 1/2

Sponsor

Novartis Pharmaceuticals

Registry

Started

2013-10-22

Enrolled

255 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

companies

Advanced Accelerator Applications (Novartis)Novartis

Evidence strength20/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
255 enrolled+12
No structured primary endpoint0
Result: active0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-17 · Jude Gomila · Link orphan sponsor companies, repoint AAA trials to Nova… · diff · file

Sources & links

ClinicalTrials.gov NCT01872260

Data

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