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Bench-top devices that 'milk' a short-lived isotope from a long-lived parent, plus vials of ready-to-label ligand. How most hospitals make PSMA and somatostatin PET tracers without a cyclotron.
Ge-68/Ga-68 generators (Eckert & Ziegler GalliaPharm, IRE ELiT Galli Eo, ITG) elute Ga-68 for 6-12 months; Mo-99/Tc-99m generators (Curium, Lantheus, GE) underpin SPECT; kits such as Illuccix and Gozellix (Telix), Locametz (Novartis) and NETSPOT (Novartis/AAA) let a radiopharmacy label PSMA-11 or DOTATATE in minutes. Generator supply shortages (Ge-68 in 2018-19) and kit versus unit-dose economics shape tracer access.
Parent isotope adsorbed on a column decays to the daughter, which is eluted on demand; cold kits contain lyophilised chelator-ligand and buffer for one-step labelling.
Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Query for this technology: (TITLE:"Radionuclide generators and cold kits" OR ABSTRACT:"Radionuclide generators and cold kits") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Radionuclide generators and cold kits, not a curated reading list.
Shares Eckert & Ziegler, Curium, Medical cyclotrons, hot cells, and synthesis modules, PET tracer manufacturing and distribution and the tag supporting.
Shares IRE (Institut national des Radioéléments), Eckert & Ziegler, Curium, Research reactors for medical isotopes (Mo-99, Lu-177, I-131) and the tag supporting.
Shares PET tracer manufacturing and distribution, Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211) and the tag supporting.
Shares PET tracer manufacturing and distribution, Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211) and the tag supporting.
Shares PET tracer manufacturing and distribution, Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211) and the tag supporting.
Shares Medical cyclotrons, hot cells, and synthesis modules and the tag supporting.
Shares Medical cyclotrons, hot cells, and synthesis modules and the tag supporting.
Shares SPECT & bone scan and the tag supporting.