{"entity":{"id":"hyperthermia","kind":"technology","name":"Hyperthermia","aka":[],"tldr":"Hyperthermia heats tumours to 40-43 °C to make radiation and chemotherapy work better.","summary":"Hyperthermia heats tumours to 40-43 °C, which impairs DNA repair and increases perfusion and drug delivery, making radiation and chemotherapy more effective without adding their toxicity. Regional and deep hyperthermia improve outcomes with radiotherapy in cervical cancer, recurrent breast cancer, and soft-tissue sarcoma (EORTC 62961). Magnetic nanoparticle hyperthermia (NanoTherm) is approved in Europe for glioblastoma. Despite this evidence it is underused outside Germany and the Netherlands, because the equipment and expertise are scarce and the technique sits awkwardly between radiotherapy and medical oncology. The simple version is that warming a tumour makes standard treatments work better, and the main barrier is access rather than evidence.","status":"established","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Hyperthermia_therapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Hyperthermia_therapy"}],"tags":[],"related":[],"cancers":["cervical","sarcoma","extremity-soft-tissue-sarcoma","glioblastoma"],"sections":["devices","radiation"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["international-journal-of-hyperthermia"],"dependsOn":[],"notes":[],"principle":"Heat impairs DNA repair and increases perfusion and drug delivery.","strengths":["Radiosensitiser without added toxicity"],"limitations":["Equipment and expertise scarce"]},"route":"/technologies/hyperthermia/","neighbours":{"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"extremity-soft-tissue-sarcoma","kind":"cancer","name":"Soft tissue sarcoma of the extremity (localised and advanced)","route":"/cancers/extremity-soft-tissue-sarcoma/"}],"section":[{"id":"devices","kind":"section","name":"Devices & Physical Therapies","route":"/fronts/devices/"},{"id":"radiation","kind":"section","name":"Radiation Therapy","route":"/fronts/radiation/"}],"journal":[{"id":"international-journal-of-hyperthermia","kind":"journal","name":"International journal of hyperthermia","route":"/journals/international-journal-of-hyperthermia/"}],"technology":[{"id":"hipec-pipac-devices","kind":"technology","name":"HIPEC perfusion pumps and PIPAC nebulisers","route":"/technologies/hipec-pipac-devices/"},{"id":"hyperthermia-systems","kind":"technology","name":"Hyperthermia systems (BSD-2000, EHY-2000, superficial and interstitial applicators)","route":"/technologies/hyperthermia-systems/"},{"id":"isolated-limb-perfusion","kind":"technology","name":"Isolated limb perfusion and infusion","route":"/technologies/isolated-limb-perfusion/"},{"id":"magnetic-nanoparticle-hyperthermia","kind":"technology","name":"Magnetic nanoparticle hyperthermia","route":"/technologies/magnetic-nanoparticle-hyperthermia/"},{"id":"radiodynamic-therapy","kind":"technology","name":"Radiodynamic therapy and radiosensitising nanoparticles","route":"/technologies/radiodynamic-therapy/"},{"id":"radiosensitisers","kind":"technology","name":"Radiosensitisers","route":"/technologies/radiosensitisers/"},{"id":"tumour-hypoxia-modification","kind":"technology","name":"Tumour hypoxia: imaging and modification","route":"/technologies/tumour-hypoxia-modification/"}],"idea":[{"id":"idea-moon-unproven-clinic-registry","kind":"idea","name":"A public registry of unproven cancer clinics and reported outcomes","route":"/ideas/idea-moon-unproven-clinic-registry/"}],"institution":[{"id":"aarhus-university-hospital","kind":"institution","name":"Aarhus University Hospital","route":"/institutions/aarhus-university-hospital/"}],"roadmap":[{"id":"devices-roadmap","kind":"roadmap","name":"Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants","route":"/roadmaps/devices-roadmap/"},{"id":"radiation-roadmap","kind":"roadmap","name":"Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH","route":"/roadmaps/radiation-roadmap/"}],"term":[{"id":"tumour-hypoxia","kind":"term","name":"Tumour hypoxia","route":"/terms/tumour-hypoxia/"}],"company":[{"id":"oncotherm","kind":"company","name":"Oncotherm","route":"/companies/oncotherm/"},{"id":"pyrexar-medical","kind":"company","name":"Pyrexar Medical","route":"/companies/pyrexar-medical/"}]}}