McGill's Goodman Cancer Institute builds on the 1965 discovery here of carcinoembryonic antigen, the first clinically used tumour marker; its groups study breast cancer metastasis, mRNA translation control and tumour metabolism, and William Muller's HER2 mouse models are used worldwide.
Founded in 1978 as the McGill Cancer Centre, the Goodman Cancer Institute builds on Phil Gold and Samuel Freedman's 1965 discovery at McGill of carcinoembryonic antigen (CEA), the first clinically used tumour marker and today the target of CEACAM5 antibody-drug conjugates. William Muller's MMTV-driven mouse models of HER2/Neu breast cancer are used worldwide; Morag Park and Peter Siegel study the breast tumour microenvironment and metastasis; Nahum Sonenberg's work on mRNA translation control (eIF4E) opened a therapeutic axis; and metabolism researchers including Julie St-Pierre link mitochondrial biology to tumour progression. The institute partners with McGill's teaching hospitals, the Jewish General Hospital's Segal Cancer Centre and the McGill University Health Centre, for translation.
Immunologist who studies why tumours resist immunotherapy and directs the Goodman Cancer Institute, McGill University's cancer research institute in Montreal.
The surgeon on CheckMate 816 who showed neoadjuvant immunotherapy does not make lung cancer operations harder.
Shares CEACAM5, HER2, Colorectal cancer.
Shares CEACAM5, HER2, Colorectal cancer.
Shares Patient-derived xenografts, Metastasis is understood least and studied last, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Lab models that fail to predict what happens in patients, Colorectal cancer.
Shares Patient-derived xenografts, Metastasis is understood least and studied last, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Metastasis is understood least and studied last, Lab models that fail to predict what happens in patients.
Shares Patient-derived xenografts, Metastasis is understood least and studied last, Melanoma, Colorectal cancer.
Shares Lab models that fail to predict what happens in patients, HER2-positive breast cancer, Melanoma.