{"entity":{"id":"mcgill-goodman","kind":"institution","name":"Rosalind and Morris Goodman Cancer Institute, McGill University","aka":["Goodman Cancer Institute","McGill Cancer Centre"],"tldr":"McGill's Goodman Cancer Institute builds on the 1965 discovery here of carcinoembryonic antigen, the first clinically used tumour marker; its groups study breast cancer metastasis, mRNA translation control and tumour metabolism, and William Muller's HER2 mouse models are used worldwide.","summary":"Founded in 1978 as the McGill Cancer Centre, the Goodman Cancer Institute builds on Phil Gold and Samuel Freedman's 1965 discovery at McGill of carcinoembryonic antigen (CEA), the first clinically used tumour marker and today the target of CEACAM5 antibody-drug conjugates. William Muller's MMTV-driven mouse models of HER2/Neu breast cancer are used worldwide; Morag Park and Peter Siegel study the breast tumour microenvironment and metastasis; Nahum Sonenberg's work on mRNA translation control (eIF4E) opened a therapeutic axis; and metabolism researchers including Julie St-Pierre link mitochondrial biology to tumour progression. The institute partners with McGill's teaching hospitals, the Jewish General Hospital's Segal Cancer Centre and the McGill University Health Centre, for translation.","asOf":"2026-09-09","links":[{"label":"Goodman Cancer Institute","url":"https://www.mcgill.ca/gci/"},{"label":"McGill University","url":"https://www.mcgill.ca"}],"tags":[],"related":[],"cancers":["breast-her2-positive","melanoma","colorectal"],"sections":["drug-discovery"],"technologies":["metabolic-therapy","pdx-models"],"targets":["ceacam5","her2"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["john-stagg","jonathan-spicer"],"bottlenecks":["b-metastasis-biology","b-preclinical-models"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Montréal, QC","country":"CA","lat":45.504,"lng":-73.577,"institutionType":"research-institute","website":"https://www.mcgill.ca/gci/","university":"McGill University","programs":["Metastasis and tumour microenvironment","Mouse models of breast cancer","Translation control and metabolism"]},"route":"/institutions/mcgill-goodman/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"section":[{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"metabolic-therapy","kind":"technology","name":"Metabolic therapy: starving the tumour of a nutrient","route":"/technologies/metabolic-therapy/"},{"id":"pdx-models","kind":"technology","name":"Patient-derived xenografts","route":"/technologies/pdx-models/"}],"target":[{"id":"ceacam5","kind":"target","name":"CEACAM5","route":"/targets/ceacam5/"},{"id":"her2","kind":"target","name":"HER2","route":"/targets/her2/"}],"person":[{"id":"john-stagg","kind":"person","name":"John Stagg","route":"/people/john-stagg/"},{"id":"jonathan-spicer","kind":"person","name":"Jonathan Spicer","route":"/people/jonathan-spicer/"}],"bottleneck":[{"id":"b-preclinical-models","kind":"bottleneck","name":"Lab models that fail to predict what happens in patients","route":"/bottlenecks/b-preclinical-models/"},{"id":"b-metastasis-biology","kind":"bottleneck","name":"Metastasis is understood least and studied last","route":"/bottlenecks/b-metastasis-biology/"}],"institution":[{"id":"muhc-cedars-cancer-centre","kind":"institution","name":"McGill University Health Centre / Cedars Cancer Centre","route":"/institutions/muhc-cedars-cancer-centre/"}],"trial":[{"id":"winther","kind":"trial","name":"WINTHER","route":"/trials/winther/"}]}}