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Trials
Dual-Targeting CAR-NK Cells in Biomarker-Selected Advanced Colorectal Cancer

trialsTrialRecruiting

Dual-Targeting CAR-NK Cells in Biomarker-Selected Advanced Colorectal Cancer

A phase 1/2 trial of EB-DUO-CAR-NK-CEA/GCC in colorectal cancer, run by Beijing Biotech, now recruiting.

Also called: DUO-CRC-NK-111

Overview Connected4

Overview

Dual-Targeting CAR-NK Cells in Biomarker-Selected Advanced Colorectal Cancer is a phase 1/2 interventional study registered as NCT07589517 by Beijing Biotech, with 48 participants planned, started 2026-02-02 and due to reach its primary completion in 2027-03-14. Interventions recorded: EB-DUO-CAR-NK-CEA/GCC and Lymphodepletion.

Setting

A Phase 1/2, Biomarker-Assigned, Open-Label Dose Escalation and Expansion Study of Allogeneic Dual-Target CAR-NK Cells Targeting CEA (CEACAM5) and/or GUCY2C (GCC) With an Exploratory HER2/ERBB2-Positive Cohort in Subjects With Advanced or Metastatic Colorectal Cancer

Phase

Phase 1/2

Sponsor

Beijing Biotech

Registry

Started

2026-02-02

Enrolled

48 enrolled

Connected

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cancers

Colorectal cancer HER2-amplified colorectal cancer

targets

Evidence strength16/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
48 enrolled+8
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 115 registry trial acronyms from the CT.gov acronym f… · diff · file

Sources & links

ClinicalTrials.gov NCT07589517

Data

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Cancers

Colorectal cancer
HER2-amplified colorectal cancer

Targets

HER2
CEACAM5

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