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Almost no research money goes to checking whether published cancer findings hold up: one replication project could complete only 23 of 50 planned experiments. Requiring 3 to 5% of every funder's research budget to go to independent replication, published whatever the result, would build the missing feedback loop.
The Reproducibility Project: Cancer Biology attempted to replicate 50 high-impact papers and could complete only 23 experiments, with effect sizes on average 85% smaller than the originals. No funder has a standing replication budget. A rule that 3 to 5% of a funder's research budget goes to independent replication of findings selected by their translational importance, with results published regardless of direction, would create the missing feedback loop.
Shares Bounties for documented failed replications of high-impact findings, Every cancer biology PhD begins with a funded replication of a published finding, Preclinical results do not reproduce.
Shares Independent replication of the key experiment before first-in-human academic trials, Preclinical results do not reproduce.
Shares Independent replication of the key experiment before first-in-human academic trials, Preclinical results do not reproduce.
Shares Funding follows fashion, not burden, Cancer Research UK, National Cancer Institute (NIH).
Shares Preclinical results do not reproduce, Cancer Research UK, National Cancer Institute (NIH).
Shares Preclinical results do not reproduce, Cancer Research UK, National Cancer Institute (NIH).
Shares Funding follows fashion, not burden, Cancer Research UK, National Cancer Institute (NIH).
Shares Funding follows fashion, not burden, Cancer Research UK, National Cancer Institute (NIH).