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A1CF (APOBEC1 complementation factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.77, genetic association 0.58, somatic mutation 0.50).
In plain words · A1CF (APOBEC1 complementation factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
A1CF (APOBEC1 complementation factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA.
No product in this corpus aims at A1CF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2000. Earliest sequence paper UniProt cites for the protein: Lellek et al, J. Biol. Chem, 2000, "Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex". Source.
Sources: HGNC HGNC:24086 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NQ94 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000148584 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Location: Nucleus; Endoplasmic reticulum; Cytoplasm (UniProt). Locus 10q11.23 (HGNC).
Query for this target: (TITLE:"A1CF" OR ABSTRACT:"A1CF" OR TITLE:"APOBEC1 complementation factor" OR ABSTRACT:"APOBEC1 complementation factor" OR TITLE:"ACF64" OR ABSTRACT:"ACF64" OR TITLE:"ACF65" OR ABSTRACT:"ACF65" OR TITLE:"APOBEC1CF" OR ABSTRACT:"APOBEC1CF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about A1CF, not a curated reading list.