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A1CF (APOBEC1 complementation factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Location: Nucleus; Endoplasmic reticulum; Cytoplasm (UniProt). Locus 10q11.23 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"A1CF" OR ABSTRACT:"A1CF" OR TITLE:"APOBEC1 complementation factor" OR ABSTRACT:"APOBEC1 complementation factor" OR TITLE:"ACF64" OR ABSTRACT:"ACF64" OR TITLE:"ACF65" OR ABSTRACT:"ACF65" OR TITLE:"APOBEC1CF" OR ABSTRACT:"APOBEC1CF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about A1CF, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/a1cf.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/a1cf.json. Licence CC BY-NC 4.0.