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BIK (Bcl-2-interacting killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.64).
In plain words · BIK (Bcl-2-interacting killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
BIK (Bcl-2-interacting killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity.
No product in this corpus aims at BIK yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: Boyd J.M. et al, Oncogene, 1995, "Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins". Source.
Sources: HGNC HGNC:1051 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13323 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100290 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: prostate cancer 0.50 (GraphQL API, CC0))
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. Location: Endomembrane system; Mitochondrion membrane (UniProt). Locus 22q13.2 (HGNC).
Query for this target: (TITLE:"BIK" OR ABSTRACT:"BIK" OR TITLE:"BCL2 interacting killer" OR ABSTRACT:"BCL2 interacting killer" OR TITLE:"Bcl-2-interacting killer" OR ABSTRACT:"Bcl-2-interacting killer") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BIK, not a curated reading list.