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ABO (Histo-blood group ABO system transferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of N-acetyl-alpha-D-galactosamine (GalNAc)) or to the B antigen (by addition of galactose (Gal)), whereas O individuals lack such activity and express the H antigen precursor unmodified.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.68).
In plain words · ABO (Histo-blood group ABO system transferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
ABO (Histo-blood group ABO system transferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H.
No product in this corpus aims at ABO yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1990. Earliest sequence paper UniProt cites for the protein: Yamamoto et al, J. Biol. Chem, 1990, "Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1-->2Gal alpha 1-->3GalNAc transferase (histo-blood group A transferase) mRNA". Source.
Sources: HGNC HGNC:79 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P16442 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000175164 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of N-acetyl-alpha-D-galactosamine (GalNAc)) or to the B antigen (by addition of galactose (Gal)), whereas O individuals lack such activity and express the H antigen precursor unmodified. Catalyses the transfer of GalNAc or Gal in an alpha1,3 linkage to the terminal Gal of all five types of naturally occurring H antigens, forming the antigenic structures of the A and B blood groups. Location: Golgi apparatus, Golgi stack membrane; Secreted (UniProt). Locus 9q34.2 (HGNC).
Query for this target: (TITLE:"ABO" OR ABSTRACT:"ABO" OR TITLE:"ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase" OR ABSTRACT:"ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase" OR TITLE:"Histo-blood group ABO system transferase" OR ABSTRACT:"Histo-blood group ABO system transferase" OR TITLE:"A3GALNT" OR ABSTRACT:"A3GALNT" OR TITLE:"A3GALT1" OR ABSTRACT:"A3GALT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABO, not a curated reading list.