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ABCC1 (ATP-binding cassette sub-family C member 1) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.84, clinical 0.12).
In plain words · ABCC1 (ATP-binding cassette sub-family C member 1) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
ABCC1 (ATP-binding cassette sub-family C member 1) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate.
No product in this corpus aims at ABCC1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ABCC1: RNA low tissue specificity; no normal tissue stained high; highest cancer staining thyroid cancer (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ABCC1 tissue; Open Targets ENSG00000103222 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Cole S.P.C. et al, Science, 1992, "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line". Source.
Sources: HGNC HGNC:51 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P33527 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000103222 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: breast cancer 0.54 (GraphQL API, CC0))
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels. Mediates the systemic release of glutathione-conjugated leukotriene C4 (LTC4) from myeloid cells such as mast cells, as part of the inflammatory response. Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centres in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma. Location: Cell membrane; Basolateral cell membrane (UniProt). Locus 16p13.11 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
No normal tissue stained high.
Medium only: endometrial cancer, glioma, head and neck cancer, lymphoma.
HPA ABCC1 tissue · HPA ABCC1 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ABCC1" OR ABSTRACT:"ABCC1" OR TITLE:"ATP binding cassette subfamily C member 1 ABCC1 blood group" OR ABSTRACT:"ATP binding cassette subfamily C member 1 ABCC1 blood group" OR TITLE:"ATP-binding cassette sub-family C member 1" OR ABSTRACT:"ATP-binding cassette sub-family C member 1" OR TITLE:"GS-X" OR ABSTRACT:"GS-X" OR TITLE:"MRP1" OR ABSTRACT:"MRP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABCC1, not a curated reading list.