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ABCB1 (ATP-dependent translocase ABCB1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Non-small-cell lung cancer and 1 more.
Translocates phospholipids and drugs across the membrane. Catalyses the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins.
CIViC holds 8 clinical evidence items and 0 assertions across 5 variants, naming Paclitaxel, Crizotinib, Alectinib and Dasatinib and others.
In plain words · ABCB1 (ATP-dependent translocase ABCB1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Non-small-cell lung cancer and 1 more.
ABCB1 (ATP-dependent translocase ABCB1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Non-small-cell lung cancer and 1 more.
Translocates phospholipids and drugs across the membrane. Catalyses the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane.
No product in this corpus aims at ABCB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ABCB1: RNA tissue enhanced (adrenal gland 96 nTPM, intestine 67 nTPM); blood lineage group enriched (NK-cells 18 nTPM, T-cells 27 nTPM); high antibody staining in 2 normal tissues; highest cancer staining liver cancer (1 of 10 high). Distribution: 4 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Ovarian cancer, Lung cancer (all types), Leukaemia); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ABCB1 tissue; Open Targets ENSG00000085563 associations
First described 1986. Earliest sequence paper UniProt cites for the protein: Chen C.-J. et al, Cell, 1986, "Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells". Source.
Sources: HGNC HGNC:40 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08183 (protein name, function text, keywords and locations (REST API)); CIViC gene ABCB1 (8 evidence items, 0 assertions, 5 variants; diseases: Lung Non-small Cell Carcinoma, Breast Cancer, Lung Adenocarcinoma, Chronic Myeloid Leukaemia, Ovarian Cancer (GraphQL API, CC0))
Translocates phospholipids and drugs across the membrane. Catalyses the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. May contribute to hepatobiliary and renal excretion of etiocholanolone-3-glucuronate. Appears to have very low activity toward testosterone, androsterone and dihydrotestosterone glucuronates. Location: Cell membrane; Apical cell membrane; Cytoplasm (UniProt). Locus 7q21.12 (HGNC).
RNA: tissue enhanced (adrenal gland 96 nTPM, intestine 67 nTPM), detected in many normal tissues. Blood: group enriched (NK-cells 18 nTPM, T-cells 27 nTPM).
Medium: Gallbladder, Liver.
RNA cancer enhanced: Kidney Renal Papillary Cell Carcinoma 35 pTPM.
Medium only: colorectal cancer, lung cancer, pancreatic cancer, renal cancer.
HPA ABCB1 tissue · HPA ABCB1 pathology · HPA protein class: CD markers
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ABCB1" OR ABSTRACT:"ABCB1" OR TITLE:"ATP binding cassette subfamily B member 1" OR ABSTRACT:"ATP binding cassette subfamily B member 1" OR TITLE:"ATP-dependent translocase ABCB1" OR ABSTRACT:"ATP-dependent translocase ABCB1" OR TITLE:"P-gp" OR ABSTRACT:"P-gp" OR TITLE:"CD243" OR ABSTRACT:"CD243" OR TITLE:"GP170" OR ABSTRACT:"GP170") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABCB1, not a curated reading list.
Shares Drug efflux pumps (ABC transporters), Epithelial-mesenchymal transition & drug efflux, CIViC, Ovarian cancer.
Shares Drug efflux pumps (ABC transporters), Breast cancer (all types).
Shares Chronic myeloid leukaemia (CML), CIViC, Breast cancer (all types).
Shares Epithelial-mesenchymal transition & drug efflux, CIViC, Non-small-cell lung cancer.
Shares Chronic myeloid leukaemia (CML), CIViC.
Shares Drug efflux pumps (ABC transporters), CIViC, Non-small-cell lung cancer.
Shares Chronic myeloid leukaemia (CML), Non-small-cell lung cancer.
Shares Chronic myeloid leukaemia (CML), Non-small-cell lung cancer.