Loading
ABCG2 (Broad substrate specificity ATP-binding cassette transporter ABCG2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants.
In plain words · ABCG2 (Broad substrate specificity ATP-binding cassette transporter ABCG2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
ABCG2 (Broad substrate specificity ATP-binding cassette transporter ABCG2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells.
No product in this corpus aims at ABCG2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ABCG2: RNA tissue enhanced (intestine 83 nTPM); high antibody staining in 8 normal tissues; highest cancer staining testis cancer (4 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ABCG2 tissue; Open Targets ENSG00000118777 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Allikmets et al, Cancer Res, 1998, "A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance". Source.
Sources: HGNC HGNC:74 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UNQ0 (protein name, function text, keywords and locations (REST API)); CIViC gene ABCG2 (1 evidence items, 0 assertions, 2 variants; diseases: Ovarian Cancer (GraphQL API, CC0))
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion. In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate. Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates. Location: Cell membrane; Apical cell membrane; Mitochondrion membrane (UniProt). Locus 4q22.1 (HGNC).
RNA: tissue enhanced (intestine 83 nTPM), detected in many normal tissues.
Medium: Kidney, Placenta, Smooth muscle, Testis.
RNA cancer enhanced: Glioblastoma Multiforme 18 pTPM.
Medium only: liver cancer, lung cancer, melanoma.
HPA ABCG2 tissue · HPA ABCG2 pathology · HPA protein class: CD markers
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ABCG2" OR ABSTRACT:"ABCG2" OR TITLE:"ATP binding cassette subfamily G member 2 JR blood group" OR ABSTRACT:"ATP binding cassette subfamily G member 2 JR blood group" OR TITLE:"Broad substrate specificity ATP-binding cassette transporter ABCG2" OR ABSTRACT:"Broad substrate specificity ATP-binding cassette transporter ABCG2" OR TITLE:"EST157481" OR ABSTRACT:"EST157481" OR TITLE:"CD338" OR ABSTRACT:"CD338") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABCG2, not a curated reading list.
Shares Drug efflux pumps (ABC transporters), Epithelial-mesenchymal transition & drug efflux, CIViC, Ovarian cancer.
Shares Epithelial-mesenchymal transition & drug efflux, CIViC.
Shares Drug efflux pumps (ABC transporters), The blood-brain barrier & brain metastasis, Epithelial-mesenchymal transition & drug efflux.
Shares Drug efflux pumps (ABC transporters), Epithelial-mesenchymal transition & drug efflux.
Shares The blood-brain barrier & brain metastasis, Ovarian cancer.
Shares The blood-brain barrier & brain metastasis, Epithelial-mesenchymal transition & drug efflux.