{"entity":{"id":"abcb1","kind":"target","name":"ABCB1","aka":["ATP binding cassette subfamily B member 1","ATP-dependent translocase ABCB1","P-gp","CD243","GP170","ABC20","p-170","PGY1","MDR1"],"tldr":"ABCB1 (ATP-dependent translocase ABCB1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Non-small-cell lung cancer and 1 more.","summary":"Translocates phospholipids and drugs across the membrane. Catalyses the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins.\n\nCIViC holds 8 clinical evidence items and 0 assertions across 5 variants, naming Paclitaxel, Crizotinib, Alectinib and Dasatinib and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:40","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:40"},{"label":"UniProt P08183","url":"https://www.uniprot.org/uniprotkb/P08183/entry"},{"label":"NCBI Gene 5243","url":"https://www.ncbi.nlm.nih.gov/gene/5243"},{"label":"Ensembl ENSG00000085563","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085563"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer","ovarian","nsclc","cml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["drug-efflux-pumps","emt"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 9 therapies; CIViC holds 8 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ABCB1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:40","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:40","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P08183","url":"https://www.uniprot.org/uniprotkb/P08183/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ABCB1","url":"https://civicdb.org/features/4244","note":"8 evidence items, 0 assertions, 5 variants; diseases: Lung Non-small Cell Carcinoma, Breast Cancer, Lung Adenocarcinoma, Chronic Myeloid Leukaemia, Ovarian Cancer (GraphQL API, CC0)"}],"distribution":"few-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ABCB1: RNA tissue enhanced (adrenal gland 96 nTPM, intestine 67 nTPM); blood lineage group enriched (NK-cells 18 nTPM, T-cells 27 nTPM); high antibody staining in 2 normal tissues; highest cancer staining liver cancer (1 of 10 high). Distribution: 4 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Ovarian cancer, Lung cancer (all types), Leukaemia); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas ABCB1 tissue","url":"https://www.proteinatlas.org/ENSG00000085563-ABCB1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000085563 associations","url":"https://platform.opentargets.org/target/ENSG00000085563/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:40","ensembl":"ENSG00000085563","uniprot":"P08183","entrez":"5243","firstDescribed":1986,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Chen C.-J. et al, Cell, 1986, \"Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2876781/","biology":"Translocates phospholipids and drugs across the membrane. Catalyses the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. May contribute to hepatobiliary and renal excretion of etiocholanolone-3-glucuronate. Appears to have very low activity toward testosterone, androsterone and dihydrotestosterone glucuronates. Location: Cell membrane; Apical cell membrane; Cytoplasm (UniProt). Locus 7q21.12 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease","Ovarian cancer: CIViC evidence names this disease","Non-small-cell lung cancer: CIViC evidence names this disease","Chronic myeloid leukaemia: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/abcb1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"pathway":[{"id":"drug-efflux-pumps","kind":"pathway","name":"Drug efflux pumps (ABC transporters)","route":"/pathways/drug-efflux-pumps/"},{"id":"emt","kind":"pathway","name":"Epithelial-mesenchymal transition & drug efflux","route":"/pathways/emt/"}]}}