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ABCB1 (ATP-dependent translocase ABCB1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Non-small-cell lung cancer and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Translocates phospholipids and drugs across the membrane. Catalyses the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. May contribute to hepatobiliary and renal excretion of etiocholanolone-3-glucuronate. Appears to have very low activity toward testosterone, androsterone and dihydrotestosterone glucuronates. Location: Cell membrane; Apical cell membrane; Cytoplasm (UniProt). Locus 7q21.12 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ABCB1" OR ABSTRACT:"ABCB1" OR TITLE:"ATP binding cassette subfamily B member 1" OR ABSTRACT:"ATP binding cassette subfamily B member 1" OR TITLE:"ATP-dependent translocase ABCB1" OR ABSTRACT:"ATP-dependent translocase ABCB1" OR TITLE:"P-gp" OR ABSTRACT:"P-gp" OR TITLE:"CD243" OR ABSTRACT:"CD243" OR TITLE:"GP170" OR ABSTRACT:"GP170") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABCB1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/abcb1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/abcb1.json. Licence CC BY-NC 4.0.