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EZR (Ezrin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.99, animal model 0.50, genetic association 0.00, somatic mutation 0.91).
In plain words · EZR (Ezrin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.
EZR (Ezrin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole.
No product in this corpus aims at EZR yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1989. Earliest sequence paper UniProt cites for the protein: Gould K.L. et al, EMBO J, 1989, "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1". Source.
Sources: HGNC HGNC:12691 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15311 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000092820 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: lung cancer 0.54 (GraphQL API, CC0))
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. Location: Apical cell membrane; Cell projection; Cell projection, microvillus membrane; Cell projection, ruffle membrane (UniProt). Locus 6q25.3 (HGNC).
Query for this target: (TITLE:"EZR" OR ABSTRACT:"EZR" OR TITLE:"ezrin" OR ABSTRACT:"ezrin" OR TITLE:"Ezrin" OR ABSTRACT:"Ezrin" OR TITLE:"VIL2" OR ABSTRACT:"VIL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EZR, not a curated reading list.