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AREG (Amphiregulin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Head and neck squamous cell carcinoma and Non-small-cell lung cancer.
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
CIViC holds 5 clinical evidence items and 0 assertions across 2 variants, naming Crizotinib, Cetuximab, Panitumumab and Docetaxel. Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.73, genetic association 0.00).
In plain words · AREG (Amphiregulin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Head and neck squamous cell carcinoma and Non-small-cell lung cancer.
AREG (Amphiregulin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Head and neck squamous cell carcinoma and Non-small-cell lung cancer.
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
No product in this corpus aims at AREG yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA AREG: RNA tissue enhanced (bone marrow 123 nTPM, placenta 309 nTPM, urinary bladder 136 nTPM); blood lineage group enriched (granulocytes 12 nTPM, NK-cells 4 nTPM); high antibody staining in 1 normal tissue. Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Colorectal cancer, Head and neck squamous cell carcinoma, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas AREG tissue; Open Targets ENSG00000109321 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Shoyab et al, Proc. Natl. Acad. Sci. U.S.A, 1988, "Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7". Source.
Sources: HGNC HGNC:651 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15514 (protein name, function text, keywords and locations (REST API)); CIViC gene AREG (5 evidence items, 0 assertions, 2 variants; diseases: Lung Non-small Cell Carcinoma, Colorectal Cancer, Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000109321 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. Location: Membrane (UniProt). Locus 4q13.3 (HGNC).
RNA: tissue enhanced (bone marrow 123 nTPM, placenta 309 nTPM, urinary bladder 136 nTPM), detected in many normal tissues. Blood: group enriched (granulocytes 12 nTPM, NK-cells 4 nTPM).
RNA cancer enhanced: Rectum Adenocarcinoma 167 pTPM.
No cancer stained high; medium in breast cancer, colorectal cancer, testis cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"AREG" OR ABSTRACT:"AREG" OR TITLE:"amphiregulin" OR ABSTRACT:"amphiregulin" OR TITLE:"Amphiregulin" OR ABSTRACT:"Amphiregulin" OR TITLE:"CRDGF" OR ABSTRACT:"CRDGF" OR TITLE:"AREGB" OR ABSTRACT:"AREGB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AREG, not a curated reading list.