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ACTG1 (Actin, cytoplasmic 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.97, genetic association 0.00).
In plain words · ACTG1 (Actin, cytoplasmic 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
ACTG1 (Actin, cytoplasmic 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
No product in this corpus aims at ACTG1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1986. Earliest sequence paper UniProt cites for the protein: Erba H.P. et al, Nucleic Acids Res, 1986, "Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes". Source.
Sources: HGNC HGNC:144 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P63261 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000184009 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage. Location: Cytoplasm, cytoskeleton (UniProt). Locus 17q25.3 (HGNC).
Query for this target: (TITLE:"ACTG1" OR ABSTRACT:"ACTG1" OR TITLE:"actin gamma 1" OR ABSTRACT:"actin gamma 1" OR TITLE:"Actin, cytoplasmic 2" OR ABSTRACT:"Actin, cytoplasmic 2" OR TITLE:"DFNA20" OR ABSTRACT:"DFNA20" OR TITLE:"DFNA26" OR ABSTRACT:"DFNA26") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACTG1, not a curated reading list.