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ADRA1D (Alpha-1D adrenergic receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1D binds the catecholamine ligands norepinephrine and epinephrine.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.29, animal model 0.26, genetic association 0.00, clinical 0.86).
In plain words · ADRA1D (Alpha-1D adrenergic receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
ADRA1D (Alpha-1D adrenergic receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11).
No product in this corpus aims at ADRA1D yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ADRA1D: RNA tissue enhanced (blood vessel 7 nTPM, brain 6 nTPM, cervix 6 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Neuroendocrine tumours); Open Targets associates it with 2 specific cancer types at or above 0.5 (benign prostatic hyperplasia, adrenal gland pheochromocytoma); the corpus evidence decides and the Open Targets list is quoted for comparison. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ADRA1D tissue; Open Targets ENSG00000171873 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Bruno J.F. et al, Biochem. Biophys. Res. Commun, 1991, "Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor". Source.
Sources: HGNC HGNC:280 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P25100 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000171873 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.51 (GraphQL API, CC0))
Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1D binds the catecholamine ligands norepinephrine and epinephrine. Location: Cell membrane (UniProt). Locus 20p13 (HGNC).
RNA: tissue enhanced (blood vessel 7 nTPM, brain 6 nTPM, cervix 6 nTPM), detected in many normal tissues.
No normal tissue stained high.
RNA cancer enhanced: Glioblastoma Multiforme 2 pTPM.
No cancer stained high; medium in liver cancer, ovarian cancer, prostate cancer, renal cancer.
HPA ADRA1D tissue · HPA ADRA1D pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ADRA1D" OR ABSTRACT:"ADRA1D" OR TITLE:"adrenoceptor alpha 1D" OR ABSTRACT:"adrenoceptor alpha 1D" OR TITLE:"Alpha-1D adrenergic receptor" OR ABSTRACT:"Alpha-1D adrenergic receptor" OR TITLE:"ADRA1R" OR ABSTRACT:"ADRA1R" OR TITLE:"ADRA1A" OR ABSTRACT:"ADRA1A" OR TITLE:"ADRA1" OR ABSTRACT:"ADRA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ADRA1D, not a curated reading list.