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BMP5 (Bone morphogenetic protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis. Initiates the canonical BMP signalling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.92, animal model 0.62, genetic association 0.58, somatic mutation 0.50).
In plain words · BMP5 (Bone morphogenetic protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
BMP5 (Bone morphogenetic protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis.
No product in this corpus aims at BMP5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1990. Earliest sequence paper UniProt cites for the protein: Celeste A.J. et al, Proc. Natl. Acad. Sci. U.S.A, 1990, "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Source.
Sources: HGNC HGNC:1072 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P22003 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000112175 (association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: colorectal cancer 0.52 (GraphQL API, CC0))
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis. Initiates the canonical BMP signalling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathway such as MAPK p38 signalling cascade to promote chondrogenic differentiation. Promotes the expression of HAMP, this is repressed by its interaction with ERFE. Location: Secreted (UniProt). Locus 6p12.1 (HGNC).
Query for this target: (TITLE:"BMP5" OR ABSTRACT:"BMP5" OR TITLE:"bone morphogenetic protein 5" OR ABSTRACT:"bone morphogenetic protein 5" OR TITLE:"Bone morphogenetic protein 5" OR ABSTRACT:"Bone morphogenetic protein 5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BMP5, not a curated reading list.