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SLC24A5 (Sodium/potassium/calcium exchanger 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.08, animal model 0.56, genetic association 0.70).
In plain words · SLC24A5 (Sodium/potassium/calcium exchanger 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
SLC24A5 (Sodium/potassium/calcium exchanger 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes.
No product in this corpus aims at SLC24A5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2001. Earliest sequence paper UniProt cites for the protein: Satoh et al, 2001, "Cloning and characterization of a novel, renal divalent cation transporter (JSX)". Source.
Sources: HGNC HGNC:20611 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q71RS6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000188467 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: skin cancer 0.52 (GraphQL API, CC0))
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes. Location: Golgi apparatus, trans-Golgi network membrane; Melanosome (UniProt). Locus 15q21.1 (HGNC).
Query for this target: (TITLE:"SLC24A5" OR ABSTRACT:"SLC24A5" OR TITLE:"solute carrier family 24 member 5" OR ABSTRACT:"solute carrier family 24 member 5" OR TITLE:"Sodium/potassium/calcium exchanger 5" OR ABSTRACT:"Sodium/potassium/calcium exchanger 5" OR TITLE:"OCA6" OR ABSTRACT:"OCA6" OR TITLE:"NCKX5" OR ABSTRACT:"NCKX5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC24A5, not a curated reading list.