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ACTB (Actin, cytoplasmic 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Actin is a highly conserved protein that polymerises to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localise in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.97, genetic association 0.00).
In plain words · ACTB (Actin, cytoplasmic 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
ACTB (Actin, cytoplasmic 1) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Actin is a highly conserved protein that polymerises to produce filaments that form cross-linked networks in the cytoplasm of cells.
No product in this corpus aims at ACTB yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA lists ACTB among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ACTB: RNA low tissue specificity; high antibody staining in 15 normal tissues; highest cancer staining colorectal cancer (7 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (Becker nevus syndrome). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ACTB tissue; Open Targets ENSG00000075624 associations
First described 1983. Earliest sequence paper UniProt cites for the protein: Hanukoglu et al, J. Mol. Biol, 1983, "Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions". Source.
Sources: HGNC HGNC:132 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P60709 (protein name, function text, keywords and locations (REST API)); CIViC gene ACTB (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000075624 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Actin is a highly conserved protein that polymerises to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localise in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. Location: Cytoplasm, cytoskeleton; Nucleus (UniProt). Locus 7p22.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Bone marrow, Endometrium, Kidney, Skeletal muscle, Testis.
Medium only: breast cancer, carcinoid, lung cancer, stomach cancer.
HPA ACTB tissue · HPA ACTB pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ACTB" OR ABSTRACT:"ACTB" OR TITLE:"actin beta" OR ABSTRACT:"actin beta" OR TITLE:"Actin, cytoplasmic 1" OR ABSTRACT:"Actin, cytoplasmic 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACTB, not a curated reading list.