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AGTRAP (Type-1 angiotensin II receptor-associated protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.89, animal model 0.26, genetic association 0.00).
In plain words · AGTRAP (Type-1 angiotensin II receptor-associated protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
AGTRAP (Type-1 angiotensin II receptor-associated protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation.
No product in this corpus aims at AGTRAP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Ye R.D. et al, 1999. Source.
Sources: HGNC HGNC:13539 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6RW13 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000177674 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. Location: Endoplasmic reticulum membrane; Golgi apparatus membrane; Cytoplasmic vesicle membrane (UniProt). Locus 1p36.22 (HGNC).
Query for this target: (TITLE:"AGTRAP" OR ABSTRACT:"AGTRAP" OR TITLE:"angiotensin II receptor associated protein" OR ABSTRACT:"angiotensin II receptor associated protein" OR TITLE:"Type-1 angiotensin II receptor-associated protein" OR ABSTRACT:"Type-1 angiotensin II receptor-associated protein" OR TITLE:"ATRAP" OR ABSTRACT:"ATRAP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AGTRAP, not a curated reading list.