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A swab tested for the virus that causes cervical cancer, more accurate than the Pap smear and doable at home.
HPV primary screening detects CIN3+ more sensitively than cytology and allows 5-year intervals; it is the WHO-recommended screening test and is standard in the Netherlands, Australia, England, and increasingly the US. Self-collected vaginal samples perform as well as clinician samples for PCR-based tests; the FDA approved self-collection in health-care settings in May 2024 and the first at-home kit in 2025. Extended genotyping and methylation triage (FAM19A4/miR124-2) reduce colposcopy referrals. Point-of-care and AI-read tests target low-resource settings.
Nucleic acid amplification or hybrid capture of high-risk HPV types (16, 18 and 12 others) from cervical or vaginal cells.
School-based vaccination at 12-13 with high uptake nearly abolishes cervical cancer in vaccinated cohorts, even with a vaccine covering only two HPV types. Screening intervals and the future of cervical screening can now be redesigned around vaccination status.
Vaccinating girls before they are exposed to HPV prevents most cervical cancers. Catch-up vaccination in young adults still helps, but less. Combined with HPV screening, elimination of cervical cancer as a public health problem is a realistic goal.
Women can collect their own screening sample at home with no loss of accuracy if the laboratory uses a PCR test. Sending kits directly is the most effective way to reach women who do not attend, which matters because most cervical cancers occur in under-screened women.
HPV DNA testing is the screening test that saves lives in low-resource settings, even when done once. The result underpins WHO's HPV-first screening guidance and India's operational guidelines, and gives the rationale for self-sampled HPV tests as the route to cervical cancer elimination.
Query for this technology: (TITLE:"HPV DNA testing and self-sampling" OR ABSTRACT:"HPV DNA testing and self-sampling") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HPV DNA testing and self-sampling, not a curated reading list.
Shares Single-dose HPV vaccination plus HPV self-sampling to reach WHO elimination in low-income countries, Harald zur Hausen, Anal high-grade squamous intraepithelial lesions (precursor), Vaginal squamous cell carcinoma (HPV-associated).
Shares Partha Basu, Single-dose HPV vaccination plus HPV self-sampling to reach WHO elimination in low-income countries, Rengaswamy Sankaranarayanan, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers.
Shares Self-collected HPV samples are as accurate as clinician samples and reach women who never attend screening, Visual inspection with acetic acid (VIA) for cervical screening, Global access and affordability roadmap: essential medicines and generics → biosimilars and frugal trials → reliance, pooling and homegrown innovation, HPV & HBV vaccination.
Shares Anal high-grade squamous intraepithelial lesions (precursor), Visual inspection with acetic acid (VIA) for cervical screening, Early cervical cancer and fertility-sparing surgery, Vaginal squamous cell carcinoma (HPV-associated).
Shares Harald zur Hausen, Anal high-grade squamous intraepithelial lesions (precursor), Vaginal squamous cell carcinoma (HPV-associated), Vaginal cancer.
Shares Swedish registry study: HPV vaccination almost eliminates cervical cancer when given before 17, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, HPV & HBV vaccination, Prevention we already have is not deployed.
Shares Self-collected HPV samples are as accurate as clinician samples and reach women who never attend screening, Visual inspection with acetic acid (VIA) for cervical screening, Prevention we already have is not deployed, Most of the world has almost no cancer care.
Shares Single-dose HPV vaccination plus HPV self-sampling to reach WHO elimination in low-income countries, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Global access and affordability roadmap: essential medicines and generics → biosimilars and frugal trials → reliance, pooling and homegrown innovation, HPV & HBV vaccination.
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
An open-source thermocycler kit for PCR, the reaction under much cancer diagnostics.