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In 131,746 rural Indian women, a single round of HPV testing roughly halved deaths from cervical cancer within eight years, while Pap smears and visual inspection did not.
Cluster-randomised trial in 52 villages of Osmanabad district, Maharashtra, comparing one round of HPV DNA testing, cytology, visual inspection with acetic acid and usual care in women aged 30 to 59. In the HPV arm there were 39 advanced cancers versus 82 in controls (hazard ratio 0.47; 95% CI 0.32-0.69) and 34 deaths versus 64 (hazard ratio 0.52; 95% CI 0.33-0.83); the cytology and visual inspection arms showed no significant reduction. Adverse events occurred in 0.1% of screened women.
HPV DNA testing is the screening test that saves lives in low-resource settings, even when done once. The result underpins WHO's HPV-first screening guidance and India's operational guidelines, and gives the rationale for self-sampled HPV tests as the route to cervical cancer elimination.
Shares Surendra Shastri, Osmanabad cervical screening trial (HPV testing vs cytology vs VIA), HPV DNA testing and self-sampling, Tata Memorial Centre.
Shares Rengaswamy Sankaranarayanan, International Agency for Research on Cancer (IARC / WHO), Prevention we already have is not deployed, The hardest cancers are found late.
Shares HPV DNA testing and self-sampling, Prevention we already have is not deployed, The hardest cancers are found late, Cervical cancer.
Shares HPV DNA testing and self-sampling, International Agency for Research on Cancer (IARC / WHO), Prevention we already have is not deployed, The hardest cancers are found late.
Shares Rengaswamy Sankaranarayanan, International Agency for Research on Cancer (IARC / WHO), Prevention we already have is not deployed, Cervical cancer.
Shares Surendra Shastri, Osmanabad cervical screening trial (HPV testing vs cytology vs VIA), HPV DNA testing and self-sampling, Cervical cancer.
Shares Rengaswamy Sankaranarayanan, Tata Memorial Centre, International Agency for Research on Cancer (IARC / WHO), Prevention we already have is not deployed.
Shares HPV DNA testing and self-sampling, International Agency for Research on Cancer (IARC / WHO), Cervical cancer.