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Among 1.7 million Swedish girls and women, quadrivalent HPV vaccination cut invasive cervical cancer by 88% when given before age 17 and by about half when given at 17-30.
A nationwide cohort of 1,672,983 girls and women aged 10-30 was followed from 2006 to 2017 through Swedish registries, linking HPV vaccination status to invasive cervical cancer diagnoses. Analyses adjusted for age, calendar year, county and parental characteristics.
Cumulative incidence of cervical cancer by age 30 was 47 per 100,000 in vaccinated women and 94 per 100,000 in unvaccinated women. The adjusted incidence rate ratio was 0.12 for women vaccinated before 17 and 0.47 for those vaccinated at 17-30.
This was the first population-level demonstration that HPV vaccination prevents invasive cancer, not just precancerous lesions.
Vaccinating girls before they are exposed to HPV prevents most cervical cancers. Catch-up vaccination in young adults still helps, but less. Combined with HPV screening, elimination of cervical cancer as a public health problem is a realistic goal.
Shares England's HPV programme: cervical cancer down 87% in the first cohort vaccinated at 12-13, HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
Shares England's HPV programme: cervical cancer down 87% in the first cohort vaccinated at 12-13, HPV & HBV vaccination, Prevention we already have is not deployed, Head and neck squamous cell carcinoma.
Shares Single-dose HPV vaccination plus HPV self-sampling to reach WHO elimination in low-income countries, HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Most of the world has almost no cancer care, Cervical cancer.
Shares England's HPV programme: cervical cancer down 87% in the first cohort vaccinated at 12-13, HPV & HBV vaccination, Cervical cancer, Head and neck squamous cell carcinoma.
Shares HPV DNA testing and self-sampling, HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Most of the world has almost no cancer care, Cervical cancer.
Shares Single-dose HPV vaccination plus HPV self-sampling to reach WHO elimination in low-income countries, HPV & HBV vaccination, Prevention we already have is not deployed, Most of the world has almost no cancer care.