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Ten years after England began vaccinating 12- to 13-year-olds with the bivalent HPV vaccine, cervical cancer in that cohort had fallen by 87% and severe precancer (CIN3) by 97%.
A population-based observational study used English cancer registry data from 2006 to 2019 to compare cervical cancer and CIN3 rates in cohorts offered the bivalent vaccine (Cervarix) at ages 12-13, 14-16 and 16-18 with earlier, unvaccinated cohorts, adjusting for changes in screening.
Relative reductions in cervical cancer were 87% in the cohort offered vaccination at 12-13, 62% at 14-16 and 34% at 16-18. CIN3 fell by 97%, 75% and 39% respectively. The authors estimated about 450 fewer cervical cancers and 17,200 fewer CIN3 cases by mid-2019.
This confirmed the Swedish finding with a different vaccine and a school-based programme with high coverage.
School-based vaccination at 12-13 with high uptake nearly abolishes cervical cancer in vaccinated cohorts, even with a vaccine covering only two HPV types. Screening intervals and the future of cervical screening can now be redesigned around vaccination status.
Shares Swedish registry study: HPV vaccination almost eliminates cervical cancer when given before 17, HPV & HBV vaccination, Prevention we already have is not deployed, Most of the world has almost no cancer care.
Shares Swedish registry study: HPV vaccination almost eliminates cervical cancer when given before 17, HPV DNA testing and self-sampling, HPV & HBV vaccination, Prevention we already have is not deployed.
Shares Swedish registry study: HPV vaccination almost eliminates cervical cancer when given before 17, HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
Shares NHS HPV vaccination programme, HPV & HBV vaccination, Cervical cancer.
Shares HPV DNA testing and self-sampling, HPV & HBV vaccination, Prevention we already have is not deployed, Cervical cancer.
Shares NHS HPV vaccination programme, HPV & HBV vaccination, Cervical cancer.
Shares Swedish registry study: HPV vaccination almost eliminates cervical cancer when given before 17, HPV & HBV vaccination, Cervical cancer.
Shares HPV & HBV vaccination, Prevention we already have is not deployed, Most of the world has almost no cancer care, Cervical cancer.