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Throat cancers caused by the human papillomavirus, identified by a p16 stain. They affect younger non-smokers and are far more curable than tobacco-related cancers.
p16 immunohistochemistry is the surrogate for HPV-driven oropharyngeal cancer (confirmed by HPV DNA/RNA where required). Incidence is rising in Western countries and now exceeds cervical cancer in the US. Separate AJCC 8th-edition staging; 3-year OS >80% with chemoradiation (RTOG 0129). De-escalation trials have so far failed to identify who can safely receive less treatment; HPV vaccination is expected to reduce incidence from the 2030s.
Showing the technology this term belongs to: HPV & HBV vaccination.
Shares Harald zur Hausen, Anal high-grade squamous intraepithelial lesions (precursor), Localised penile cancer (organ-confined, node-negative), HPV-associated vulvar squamous cell carcinoma.
Shares Anal high-grade squamous intraepithelial lesions (precursor), Localised penile cancer (organ-confined, node-negative), Node-positive and metastatic penile cancer, Vaginal squamous cell carcinoma (HPV-associated).
Shares Anal high-grade squamous intraepithelial lesions (precursor), Localised penile cancer (organ-confined, node-negative), HPV-independent vulvar squamous cell carcinoma (p53-mutant), HPV-associated vulvar squamous cell carcinoma.
Shares Harald zur Hausen, Anal high-grade squamous intraepithelial lesions (precursor), Vaginal squamous cell carcinoma (HPV-associated), Vaginal cancer.
Shares HPV-associated vulvar squamous cell carcinoma, Vaginal squamous cell carcinoma (HPV-associated), Vaginal cancer, Vulvar cancer.
Shares PATHOS, Small cell neuroendocrine carcinoma of the cervix, Adenosquamous carcinoma of the cervix, Squamous cell carcinoma of the urethra.
Shares PATHOS, ECOG-ACRIN E3311, HPV-positive oropharyngeal cancer, Head and neck squamous cell carcinoma.
Shares PATHOS, ECOG-ACRIN E3311, NRG-HN002 & NRG-HN005 (HPV+ de-escalation), HPV-positive oropharyngeal cancer.