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A blood test that detects fragments of the virus DNA shed by HPV-positive throat cancers, to confirm diagnosis, track response, and catch recurrence early.
Digital droplet PCR or NGS assays (NavDx, others) detect HPV16 DNA in plasma with high specificity; clearance during chemoradiation predicts cure and post-treatment surveillance detects recurrence months before imaging. Being used to select patients for response-adapted de-escalation after the failure of HPV-status-alone selection (NRG-HN005).
Tumour-tissue-modified viral DNA fragments quantified in cell-free plasma DNA.
Query for this technology: (TITLE:"Circulating tumour HPV DNA" OR ABSTRACT:"Circulating tumour HPV DNA" OR TITLE:"ctHPV-DNA" OR ABSTRACT:"ctHPV-DNA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Circulating tumour HPV DNA (ctHPV-DNA), not a curated reading list.
Shares Caution: de-escalating radiation on HPV status alone, ctHPV-DNA-adapted de-escalation of chemoradiation, HPV-positive (p16) head and neck cancer, HPV-positive oropharyngeal cancer.
Shares Localised anal squamous cell carcinoma (stage I to III), Metastatic and recurrent anal squamous cell carcinoma.
Shares Anal high-grade squamous intraepithelial lesions (precursor), Anal cancer (squamous cell carcinoma).
Shares HPV-positive (p16) head and neck cancer, HPV-positive oropharyngeal cancer, Head and neck squamous cell carcinoma.
Shares Plasma EBV DNA, Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA), Head and neck squamous cell carcinoma.
Shares Plasma EBV DNA, Liquid biopsy (ctDNA), Head and neck squamous cell carcinoma.
Shares Anal high-grade squamous intraepithelial lesions (precursor), Anal cancer (squamous cell carcinoma).
Shares Circulating tumour DNA (ctDNA), MRD / molecular residual disease testing, Liquid biopsy (ctDNA).