Loading
A vaccine against nine HPV types that prevents about 90% of cervical cancers, and now works with a single dose.
Approved 2014 (US), covering HPV 6, 11, 16, 18, 31, 33, 45, 52, 58. Population data from Sweden (NEJM 2020) and Scotland (JNCI 2024) show ~90% and near-100% reductions in invasive cervical cancer in women vaccinated at 12-13. WHO recommends one- or two-dose schedules since 2022 (KEN SHE, IARC India); FDA label remains two doses under 15 and three doses at 15-45. Also prevents anal, oropharyngeal, vulvar, vaginal, and penile cancers and genital warts. Global coverage of girls with at least one dose was ~27% in 2023, the binding constraint on elimination.
Recombinant L1 capsid proteins self-assemble into virus-like particles that induce high-titre neutralising antibodies preventing persistent oncogenic HPV infection.
1.L1 protein particles mimic the virus shell without DNA
Medicare Part D covers ACIP-recommended vaccines, including HPV vaccine for eligible adults through age 45, at no cost since 2023 under the Inflation Reduction Act; Part B does not cover it. Most Medicare beneficiaries are outside the recommended age range.
ACA-compliant commercial plans cover ACIP-recommended vaccines with no cost sharing in network, including HPV vaccination through age 26 and shared decision-making for 27 to 45. Medicaid and the Vaccines for Children programme cover children and adolescents.
Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap) · Medicare.gov: Vaccines covered by Part D at no cost · HealthCare.gov: Preventive care benefits for adults. Not medical or financial advice; verify with your plan.
Sources: NICE search: Gardasil 9 (HPV vaccine). Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Original quadrivalent Gardasil approved
Gardasil 9 approved
One-dose schedule endorsed (SAGE)
| Region | Year | Indication |
|---|---|---|
| US | 2014 | Prevention of HPV-related cancers and precancers, ages 9-26; extended to 45 in 2018 |
| WHO | 2022 | Single-dose schedule recommended for girls 9-20 |
| Adverse event | Any grade | Grade 3+ |
|---|---|---|
| Injection-site pain | 90% | - |
| Syncope (adolescents) | - | - |
Observe 15 minutes after injection. Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"Nonavalent HPV vaccine" OR ABSTRACT:"Nonavalent HPV vaccine" OR TITLE:"Gardasil 9" OR ABSTRACT:"Gardasil 9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Nonavalent HPV vaccine, not a curated reading list.
Shares Harald zur Hausen, Anal high-grade squamous intraepithelial lesions (precursor), Localised penile cancer (organ-confined, node-negative), HPV-associated vulvar squamous cell carcinoma.
Shares Single-dose HPV vaccination plus HPV self-sampling to reach WHO elimination in low-income countries, Anal high-grade squamous intraepithelial lesions (precursor), Localised penile cancer (organ-confined, node-negative), HPV-associated vulvar squamous cell carcinoma.
Shares HPV quadrivalent vaccine (types 6, 11, 16 and 18), HPV-associated vulvar squamous cell carcinoma, Vaginal squamous cell carcinoma (HPV-associated), Vaginal cancer.
Shares Harald zur Hausen, Anal high-grade squamous intraepithelial lesions (precursor), Vaginal squamous cell carcinoma (HPV-associated), Vaginal cancer.
Shares Anal high-grade squamous intraepithelial lesions (precursor), Localised penile cancer (organ-confined, node-negative), Vaginal squamous cell carcinoma (HPV-associated), Penile cancer.
Shares Single-dose HPV vaccination plus HPV self-sampling to reach WHO elimination in low-income countries, Harald zur Hausen, Anal high-grade squamous intraepithelial lesions (precursor), Vaginal squamous cell carcinoma (HPV-associated).
Shares Ian Frazer, Harald zur Hausen, HPV & HBV vaccination, Prevention we already have is not deployed.
Shares Vaccines for Children program (US), NHS HPV vaccination programme, HPV & HBV vaccination, Cervical cancer.