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Gardasil was the first HPV vaccine, licensed in 2006 to prevent cervical and other genital cancers and genital warts. It has been replaced in most countries by the nine-type version, Gardasil 9.
The quadrivalent HPV vaccine was approved by the FDA in June 2006 for females aged 9 to 26 to prevent cervical, vulvar and vaginal cancers and precancers and genital warts caused by HPV 6, 11, 16 and 18, on the FUTURE I and II trials, with males (2009) and anal cancer prevention (2010) added; the EU authorised Gardasil in September 2006. It was the first vaccine indicated to prevent a cancer, and population data from Australia, Scandinavia and the UK have since shown large falls in cervical precancer and invasive cancer in vaccinated cohorts. Gardasil 9, covering five further oncogenic types, replaced it in the US in 2017 and in most programmes since. Syncope after injection and injection-site reactions are the main adverse effects; extensive surveillance has found no link to autoimmune disease.
L1 virus-like particles of HPV types 6, 11, 16 and 18 on an aluminium adjuvant induce neutralising antibodies that prevent the infections behind most cervical, anal, vulvar and vaginal cancers and genital warts.
1.HPV quadrivalent vaccine (types 6, 11, 16 and 18) slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| US | 2006 | Prevention of cervical, vulvar and vaginal cancers and precancers and genital warts caused by HPV 6, 11, 16 and 18 in females 9 to 26 (males 2009; anal cancer 2010); superseded by Gardasil 9 |
| EU | 2006 | Prevention of premalignant genital lesions, cervical cancer and genital warts from age 9 (Gardasil); anal lesions and cancer added later |
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Query for this drug: (TITLE:"HPV quadrivalent vaccine" OR ABSTRACT:"HPV quadrivalent vaccine" OR TITLE:"types 6, 11, 16 and 18" OR ABSTRACT:"types 6, 11, 16 and 18" OR TITLE:"Gardasil" OR ABSTRACT:"Gardasil" OR TITLE:"Silgard" OR ABSTRACT:"Silgard") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HPV quadrivalent vaccine (types 6, 11, 16 and 18), not a curated reading list.
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