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Cervarix is a vaccine against HPV types 16 and 18, the two types that cause most cervical cancers, authorised in the EU in 2007 and the US in 2009 after the 18,000-woman PATRICIA trial showed near-complete protection against type-specific precancer. GSK withdrew it from the US in 2016, but it remains WHO-prequalified and used in national programmes, including single-dose schedules.
The bivalent HPV vaccine was authorised in the EU in September 2007 and approved by the FDA in October 2009 for prevention of cervical cancer, cervical intraepithelial neoplasia and adenocarcinoma in situ caused by HPV 16 and 18 in females aged 9 to 25 (10 to 25 in the US), on the PATRICIA phase 3 trial of more than 18,000 women, which showed near-complete protection against type-specific CIN2+ in HPV-naive women and cross-protection against types 31, 33 and 45. GSK withdrew it from the US market in 2016 for commercial reasons; it remains WHO-prequalified and is used in national programmes, including single-dose schedules supported by the KEN SHE trial and the Costa Rica Vaccine Trial follow-up. Injection-site pain and fatigue are the main adverse effects.
L1 capsid virus-like particles of HPV types 16 and 18 with the AS04 adjuvant induce neutralising antibodies that prevent persistent infection with the two types responsible for about 70% of cervical cancers.
1.HPV bivalent vaccine (types 16 and 18) slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| EU | 2007 | Prevention of premalignant cervical lesions and cervical cancer caused by HPV 16 and 18 from age 9 (Cervarix); anal lesions added later |
| US | 2009 | Prevention of cervical cancer and precursor lesions caused by HPV 16 and 18 in females 10 to 25 (discontinued in the US 2016) |
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Query for this drug: (TITLE:"HPV bivalent vaccine" OR ABSTRACT:"HPV bivalent vaccine" OR TITLE:"types 16 and 18" OR ABSTRACT:"types 16 and 18" OR TITLE:"Cervarix" OR ABSTRACT:"Cervarix") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HPV bivalent vaccine (types 16 and 18), not a curated reading list.
Shares HPV quadrivalent vaccine (types 6, 11, 16 and 18), Cancer interception vaccines, HPV & HBV vaccination, Cervical cancer.
Shares HPV quadrivalent vaccine (types 6, 11, 16 and 18), Cancer interception vaccines, HPV & HBV vaccination.
Shares HPV & HBV vaccination, Cervical cancer and the tag prevention.
Shares HPV & HBV vaccination, Cervical cancer and the tag prevention.
Shares Cervical cancer and the tag prevention.
Shares Nonavalent HPV vaccine, HPV & HBV vaccination, Cervical cancer.
Shares Nonavalent HPV vaccine, HPV & HBV vaccination, Cervical cancer.
Shares Nonavalent HPV vaccine, HPV & HBV vaccination, Cervical cancer.