Loading
RTOG 1016 tried to spare HPV-positive throat cancer patients the toxicity of cisplatin by using cetuximab instead, and found that survival was worse: cisplatin stays the standard.
RTOG 1016 randomised 987 patients with HPV-positive oropharyngeal squamous cell carcinoma to accelerated radiotherapy with cisplatin or with cetuximab. Five-year overall survival was 84.6 percent with cisplatin and 77.9 percent with cetuximab, failing non-inferiority, and locoregional failure was higher with cetuximab; overall toxicity was similar (Gillison and colleagues, Lancet 2019). Together with De-ESCALaTE it closed the door on antibody substitution in this good-prognosis disease.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
987 enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Overall survival at 5 yearsprimary | Radiotherapy plus cisplatin | 406 | 84.6% | - | - | - |
| Radiotherapy plus cetuximab | 399 | 77.9% |
Shares HPV-positive oropharyngeal cancer, Oropharyngeal cancer (tonsil and base of tongue), HPV DNA testing and self-sampling, Chemoradiation (chemoradiotherapy, CRT) and the tag radiation-wave4.
Shares Oropharyngeal cancer (tonsil and base of tongue), Cetuximab, Head and neck squamous cell carcinoma, IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares NRG Oncology, Chemoradiation (chemoradiotherapy, CRT), Cisplatin, Head and neck squamous cell carcinoma and the tag radiation-wave4.
Shares NRG Oncology, Chemoradiation (chemoradiotherapy, CRT), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Chemoradiation (chemoradiotherapy, CRT), Cisplatin, IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Chemoradiation (chemoradiotherapy, CRT), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares NRG Oncology, IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Chemoradiation (chemoradiotherapy, CRT), IMRT / IGRT (modern external beam) and the tag radiation-wave4.