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EORTC 26951, the European twin of RTOG 9402, confirmed that PCV chemotherapy after radiotherapy greatly lengthens survival in 1p/19q co-deleted oligodendrogliomas.
EORTC 26951 randomised 368 patients with anaplastic oligodendroglioma or oligoastrocytoma to 59.4 Gy radiotherapy with or without six cycles of adjuvant PCV. With a median follow-up of nearly 12 years, overall survival improved with PCV (42.3 versus 30.6 months overall); in 1p/19q co-deleted tumours median survival was not reached with PCV versus 112 months with radiotherapy alone (van den Bent and colleagues, Journal of Clinical Oncology 2013).
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
368 enrolled.
Shares Lomustine (CCNU), Procarbazine, Oligodendroglioma, IDH-mutant and 1p/19q-codeleted, Brain and spinal cord tumours (all types) and the tag radiation-wave4.
Shares Oligodendroglioma, IDH-mutant and 1p/19q-codeleted, EORTC, Brain and spinal cord tumours (all types), Glioma & glioblastoma and the tag radiation-wave4.
Shares Chemoradiation (chemoradiotherapy, CRT), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Chemoradiation (chemoradiotherapy, CRT), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Chemoradiation (chemoradiotherapy, CRT), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Chemoradiation (chemoradiotherapy, CRT), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Chemoradiation (chemoradiotherapy, CRT), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Chemoradiation (chemoradiotherapy, CRT), IMRT / IGRT (modern external beam) and the tag radiation-wave4.