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Brachytherapy places a radioactive source directly inside or next to the tumour.
Brachytherapy places sealed radioactive sources (192Ir, 125I, 103Pd) directly inside or next to the tumour, so the dose falls off steeply from within and gives the highest conformality of any radiotherapy technique. It is a mandatory, curative component of cervical cancer treatment, is used in prostate cancer as LDR seed implants or HDR, and is applied in breast (partial-breast), skin, and eye, where plaque brachytherapy treats uveal melanoma. Treatment courses are short compared with external beam. The approach is invasive, requiring an implant procedure, and expertise is declining in some regions even where the evidence is strongest, which is a concern in cervical cancer. The simple version is that the radiation source is put inside the tumour rather than beamed in from outside.
Sealed sources (192Ir, 125I, 103Pd) deliver steep dose fall-off from within.
Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
The survival gain turns the earlier progression-free survival result into a clear reason to offer pembrolizumab with and after chemoradiotherapy to women with node-positive or stage III-IVA cervical cancer. Because cervical cancer is concentrated in low- and middle-income countries, the benefit reaches most women only if pricing and access follow.
Women with locally advanced cervical cancer that is node-positive or stage III-IVA can be offered pembrolizumab alongside and after chemoradiotherapy to lower the chance of relapse. The result matters most in countries where cervical cancer is common but immunotherapy access is poorest, so its global impact depends on pricing and health-system capacity. It does not apply to early-stage disease treated with surgery or to lower-risk locally advanced disease without nodal involvement.
Query for this technology: (TITLE:"brachytherapy" OR ABSTRACT:"brachytherapy"). Results are unfiltered search hits about Brachytherapy, not a curated reading list.
Shares Dharmais National Cancer Center, Institut National d'Oncologie, Rabat, Institut Salah Azaïez, Ocean Road Cancer Institute.
Shares Dharmais National Cancer Center, Institut National d'Oncologie, Rabat, Ocean Road Cancer Institute, Instituto Nacional de Enfermedades Neoplásicas.
Shares Carien L. Creutzberg, Induction chemotherapy → chemoradiation (locally advanced cervical cancer), Mary McCormack, Surgery against radiotherapy for basal cell carcinoma of the face.
Shares Empyrean Medical Systems, A translation fund for academic surgical devices and radiotherapy technology, American Society for Radiation Oncology, Intraoperative radiotherapy (IORT).
Shares Dharmais National Cancer Center, Institut Salah Azaïez, Ho Chi Minh City Oncology Hospital, Instituto Nacional de Enfermedades Neoplásicas.
Shares Early cervical cancer and fertility-sparing surgery, POLE-ultramutated endometrial cancer, Uterine carcinosarcoma, p53-abnormal endometrial cancer, including uterine serous carcinoma.
Shares A translation fund for academic surgical devices and radiotherapy technology, American Society for Radiation Oncology, European Society for Radiotherapy and Oncology, Sunnybrook Odette Cancer Centre.
Shares Dharmais National Cancer Center, Institut Salah Azaïez, Radiotherapy for everyone who needs it by 2040, Blended finance and a low-cost linac to close the global radiotherapy gap.
Open-source software, hardware and data projects catalogued by a third party, the Open Medical Registry, that bear on this technology. Listing is not endorsement; check each project's own licence and validation before clinical use.
Online Radiation Therapy BED EQD2 comparision schemes and Reirradiation analysis based on Python and Streamlit
3D Slicer extension for Radiotherapy clinical re-irradiation analysis.
From the Open Medical Registry (openmedical.sh), an MIT-licensed catalogue of open-source medicine. Blurbs are one line from each registry record; every project keeps its own licence.