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Giving a single large dose of radiation directly to the tumour bed during surgery, with normal organs moved out of the way; used mainly in breast cancer as an alternative to weeks of external radiotherapy.
IORT delivers 10-21 Gy in one fraction via electrons (mobile linacs, ELIOT), low-energy X-rays (Intrabeam, TARGIT) or HDR brachytherapy applicators. In early breast cancer, TARGIT-A (BMJ 2020, long-term) showed risk-adapted IORT non-inferior for local recurrence with fewer non-breast-cancer deaths, while ELIOT (Lancet Oncol 2021) showed higher local recurrence with electron IORT than whole-breast RT (though survival was equal); ASTRO regards it as suitable for selected low-risk patients within trials or registries. Other uses: locally advanced rectal cancer and retroperitoneal sarcoma (margin boost), pancreatic cancer, paediatric tumours. Competing partial-breast approaches (5-fraction external APBI, brachytherapy) and FLASH radiotherapy overlap.
Direct visualisation and displacement of organs at risk allow a large single fraction to the highest-risk tissue with steep dose fall-off, exploiting the radiobiology of high dose per fraction.
One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Query for this technology: (TITLE:"Intraoperative radiotherapy" OR ABSTRACT:"Intraoperative radiotherapy" OR TITLE:"IORT" OR ABSTRACT:"IORT") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Intraoperative radiotherapy (IORT), not a curated reading list.
Shares TARGIT-A (targeted intraoperative radiotherapy), Partial-breast irradiation, Breast cancer (all types), IMRT / IGRT (modern external beam).
Shares TARGIT-A (targeted intraoperative radiotherapy), Partial-breast irradiation, Breast cancer (all types), IMRT / IGRT (modern external beam).
Shares TARGIT-A (targeted intraoperative radiotherapy), Partial-breast irradiation, Breast cancer (all types), IMRT / IGRT (modern external beam).
Shares IntraOp Medical, Electron beam therapy systems (linac electrons, total skin electron units, mobile electron IORT), FLASH radiotherapy.
Shares Remote afterloaders for HDR brachytherapy, Partial-breast irradiation, Brachytherapy.
Shares Remote afterloaders for HDR brachytherapy, Electron beam therapy systems (linac electrons, total skin electron units, mobile electron IORT), FLASH radiotherapy, Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH.
Shares FLASH radiotherapy, Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH, IMRT / IGRT (modern external beam).
Shares Remote afterloaders for HDR brachytherapy, Electron beam therapy systems (linac electrons, total skin electron units, mobile electron IORT), Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH, Brachytherapy.