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IMPORT LOW showed that treating only the part of the breast around the tumour bed, with the same simple technique and schedule, is as safe as whole-breast radiotherapy and causes fewer changes to the breast.
IMPORT LOW randomised 2,018 women with low-risk breast cancer to whole-breast radiotherapy, whole-breast with reduced dose outside the tumour bed, or partial-breast radiotherapy only, all 40 Gy in 15 fractions with standard tangential fields. Five-year local relapse was 1.1 percent after whole-breast and 0.5 percent after partial-breast treatment, non-inferior, with fewer reported changes in breast appearance (Coles and colleagues, Lancet 2017).
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
2,018 enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Local relapse at 5 yearsprimary | Partial-breast radiotherapy | 674 | 0.5% | - | - | - |
| Whole-breast radiotherapy | 674 | 1.1% |
Shares RAPID (accelerated partial-breast irradiation), TARGIT-A (targeted intraoperative radiotherapy), Partial-breast irradiation, HER2-positive breast cancer and the tag radiation-wave2.
Shares Partial-breast irradiation, Hypofractionated radiotherapy, The Institute of Cancer Research, HER2-positive breast cancer and the tag radiation-wave2.
Shares Partial-breast irradiation, Hypofractionated radiotherapy, HER2-positive breast cancer, Breast cancer (all types) and the tag radiation-wave2.
Shares Hypofractionated radiotherapy, The Institute of Cancer Research, IMRT / IGRT (modern external beam) and the tag radiation-wave2.
Shares Breast cancer (all types), IMRT / IGRT (modern external beam), HR-positive / HER2-negative breast cancer and the tag radiation-wave2.
Shares Breast cancer (all types), IMRT / IGRT (modern external beam), HR-positive / HER2-negative breast cancer and the tag radiation-wave2.
Shares Hypofractionated radiotherapy, The Institute of Cancer Research and the tag radiation-wave2.
Shares Breast cancer (all types), HR-positive / HER2-negative breast cancer and the tag radiation-wave2.