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CALGB 9343 showed that older women with small hormone-sensitive breast cancers taking tamoxifen gain only a small reduction in local recurrence from radiotherapy and no survival benefit, opening the door to omitting it.
CALGB 9343 randomised 636 women aged 70 or older with clinical stage I oestrogen receptor-positive breast cancer treated by lumpectomy to tamoxifen alone or tamoxifen plus radiotherapy. At ten years, locoregional recurrence was 10 percent without and 2 percent with radiotherapy, with no difference in mastectomy rates, distant disease or overall survival (Hughes and colleagues, New England Journal of Medicine 2004 and Journal of Clinical Oncology 2013). Guidelines now list radiotherapy omission as an option in this group.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
636 enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Locoregional recurrence at 10 yearsprimary | Tamoxifen alone | 319 | 10% | - | - | - |
| Tamoxifen plus radiotherapy | 317 | 2% |
One trial page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One trial page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Shares Breast cancer (all types), IMRT / IGRT (modern external beam), HR-positive / HER2-negative breast cancer and the tag radiation-wave2.
Shares Breast cancer (all types), IMRT / IGRT (modern external beam), HR-positive / HER2-negative breast cancer and the tag radiation-wave2.
Shares Breast cancer (all types), IMRT / IGRT (modern external beam), HR-positive / HER2-negative breast cancer and the tag radiation-wave2.
Shares Breast cancer (all types), IMRT / IGRT (modern external beam), HR-positive / HER2-negative breast cancer and the tag radiation-wave2.
Shares Alliance for Clinical Trials in Oncology and the tag radiation-wave2.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave2.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave2.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave2.