{"entity":{"id":"import-low","kind":"trial","name":"IMPORT LOW","aka":[],"tldr":"IMPORT LOW showed that treating only the part of the breast around the tumour bed, with the same simple technique and schedule, is as safe as whole-breast radiotherapy and causes fewer changes to the breast.","summary":"IMPORT LOW randomised 2,018 women with low-risk breast cancer to whole-breast radiotherapy, whole-breast with reduced dose outside the tumour bed, or partial-breast radiotherapy only, all 40 Gy in 15 fractions with standard tangential fields. Five-year local relapse was 1.1 percent after whole-breast and 0.5 percent after partial-breast treatment, non-inferior, with fewer reported changes in breast appearance (Coles and colleagues, Lancet 2017).","status":"positive","asOf":"2026-09-16","links":[{"label":"ISRCTN12852634","url":"https://www.isrctn.com/ISRCTN12852634"},{"label":"Lancet 2017","url":"https://doi.org/10.1016/S0140-6736(17)31145-5"}],"tags":["radiation-wave2"],"related":[],"cancers":["breast-hr-positive","breast-her2-positive","tnbc","breast-cancer"],"sections":[],"technologies":["hypofractionated-radiotherapy","imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":["icr-london"],"pathways":[],"terms":["partial-breast-irradiation","tumour-bed-boost"],"trials":["rapid","targit-a","eortc-22881-boost"],"people":[],"bottlenecks":[],"keyPapers":["paper-coles-lancet"],"journals":[],"dependsOn":[],"notes":[],"phase":"3","setting":"Low-risk early breast cancer: partial-breast or reduced-dose radiotherapy versus whole-breast radiotherapy, 40 Gy in 15 fractions","sponsor":"Institute of Cancer Research (UK)","result":"5-year local relapse 0.5% (partial breast) vs 1.1% (whole breast), non-inferior; fewer breast changes.","yearReported":2017,"enrolled":2018,"enrolledBasis":"registry","outcomes":[{"endpoint":"Local relapse at 5 years","primary":true,"unit":"%","arms":[{"name":"Partial-breast radiotherapy","n":674,"value":0.5},{"name":"Whole-breast radiotherapy","n":674,"value":1.1}]}]},"route":"/trials/import-low/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"technology":[{"id":"hypofractionated-radiotherapy","kind":"technology","name":"Hypofractionated radiotherapy","route":"/technologies/hypofractionated-radiotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"institution":[{"id":"icr-london","kind":"institution","name":"The Institute of Cancer Research","route":"/institutions/icr-london/"}],"term":[{"id":"partial-breast-irradiation","kind":"term","name":"Partial-breast irradiation","route":"/terms/partial-breast-irradiation/"},{"id":"tumour-bed-boost","kind":"term","name":"Tumour bed boost","route":"/terms/tumour-bed-boost/"}],"trial":[{"id":"eortc-22881-boost","kind":"trial","name":"EORTC 22881-10882 (boost against no boost)","route":"/trials/eortc-22881-boost/"},{"id":"rapid","kind":"trial","name":"RAPID (accelerated partial-breast irradiation)","route":"/trials/rapid/"},{"id":"targit-a","kind":"trial","name":"TARGIT-A (targeted intraoperative radiotherapy)","route":"/trials/targit-a/"}],"paper":[{"id":"paper-coles-lancet","kind":"paper","name":"Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial","route":"/key-papers/paper-coles-lancet/"}]}}