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Delivering an entire dose in under a second, which in animals spares healthy tissue while still killing the tumour.
FLASH radiotherapy delivers the entire dose in milliseconds rather than minutes, at ultra-high dose rates above 40 Gy/s, and in preclinical models this spares normal tissue while killing the tumour equally well. First-in-human trials (FAST-01/02 with protons, Varian; electron trials in Lausanne) show feasibility. The mechanism, proposed as oxygen depletion or radical recombination, is debated, and the clinical effect is unproven. If real, the effect could widen the therapeutic window dramatically, but hardware constraints make it hard to reach deep tumours with current machines. The simple version is that giving radiation in a fraction of a second may protect healthy tissue, and human trials are only now testing whether that holds.
Dose delivered in milliseconds rather than minutes; differential normal-tissue sparing.
Query for this technology: (TITLE:"FLASH radiotherapy" OR ABSTRACT:"FLASH radiotherapy" OR TITLE:"ultra-high dose rate radiotherapy" OR ABSTRACT:"ultra-high dose rate radiotherapy"). Results are unfiltered search hits about FLASH radiotherapy, not a curated reading list.
Shares Pencil-beam scanning and intensity-modulated proton therapy, Varian (Siemens Healthineers), Proton therapy machines: cyclotrons, synchrotrons and single-room systems, Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tag frontier.
Shares Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tag frontier.
Shares NCT/UCC Dresden, University Hospital Carl Gustav Carus and the tag frontier.
Shares Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tag frontier.
Shares Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tag frontier.
Shares Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tag frontier.
Shares Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tag frontier.
Shares Compact FLASH and proton systems at the price of a conventional linac, A coordinated FLASH radiotherapy evidence programme with shared dose-rate standards, Radiotherapy QA phantoms and dosimeters (Sun Nuclear, IBA Dosimetry, PTW), Proton therapy machines: cyclotrons, synchrotrons and single-room systems.