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BUB1 is one of the kinases that stops a dividing cell pulling its chromosomes apart before every one is attached. Inhibitors exist in the laboratory; none has reached patients.
BUB1 (chromosome 2q13) is a serine/threonine kinase essential for spindle-assembly-checkpoint signalling and correct chromosome alignment: it assembles checkpoint proteins at the kinetochore, being required for the localisation of CENPF, BUB1B, CENPE and MAD2L1 and of PLK1, and for centromeric enrichment of cohesion factors. Expression is high in testis and thymus, lower in colon, spleen, lung and small intestine, and associated with tissues of high mitotic index (UniProt O43683). A ClinicalTrials.gov search for the tool inhibitor BAY 1816032 returned no studies.
In plain words · BUB1 is one of the kinases that stops a dividing cell pulling its chromosomes apart before every one is attached. Inhibitors exist in the laboratory; none has reached patients.
BUB1 is one of the kinases that stops a dividing cell pulling its chromosomes apart before every one is attached. Inhibitors exist in the laboratory; none has reached patients.
A kinetochore kinase of the spindle assembly checkpoint, alongside MPS1 (TTK) and BUB1B.
No product in this corpus aims at BUB1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 1997. Earliest sequence paper UniProt cites for the protein: Pangilinan et al, Genomics, 1997, "Mammalian BUB1 protein kinases: map positions and in vivo expression". Source.
Sources: HGNC HGNC:1148 (approved symbol, name, aliases and cross-references); UniProt O43683 (protein name, function and tissue specificity)
A kinetochore kinase of the spindle assembly checkpoint, alongside MPS1 (TTK) and BUB1B.
Query for this target: (TITLE:"BUB1" OR ABSTRACT:"BUB1" OR TITLE:"BUB1 mitotic checkpoint serine/threonine kinase" OR ABSTRACT:"BUB1 mitotic checkpoint serine/threonine kinase" OR TITLE:"hBUB1" OR ABSTRACT:"hBUB1" OR TITLE:"BUB1L" OR ABSTRACT:"BUB1L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BUB1, not a curated reading list.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.