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AURKB (Aurora kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Alisertib, Barasertib and Copanlisib.
In plain words · AURKB (Aurora kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
AURKB (Aurora kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
No product in this corpus aims at AURKB yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Broadly expressed or essential: HPA lists AURKB among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA AURKB: RNA tissue enhanced (bone marrow 42 nTPM, lymphoid tissue 56 nTPM); blood lineage group enriched (B-cells 3 nTPM, T-cells 8 nTPM); high antibody staining in 6 normal tissues; highest cancer staining colorectal cancer (6 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Head and neck squamous cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas AURKB tissue; Open Targets ENSG00000178999 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Zhang et al, 1997, "Cloning of a novel human gene homologous to mouse STK-1". Source.
Sources: HGNC HGNC:11390 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96GD4 (protein name, function text, keywords and locations (REST API)); CIViC gene AURKB (1 evidence items, 0 assertions, 1 variants; diseases: Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0))
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signalling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Location: Nucleus; Chromosome; Chromosome, centromere; Chromosome, centromere, kinetochore (UniProt). Locus 17p13.1 (HGNC).
RNA: tissue enhanced (bone marrow 42 nTPM, lymphoid tissue 56 nTPM), detected in many normal tissues. Blood: group enriched (B-cells 3 nTPM, T-cells 8 nTPM).
Medium: Bone marrow, Lymph node, Tonsil, Vagina.
Medium only: breast cancer, carcinoid, glioma, head and neck cancer.
HPA AURKB tissue · HPA AURKB pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"AURKB" OR ABSTRACT:"AURKB" OR TITLE:"aurora kinase B" OR ABSTRACT:"aurora kinase B" OR TITLE:"Aurora kinase B" OR ABSTRACT:"Aurora kinase B" OR TITLE:"Aik2" OR ABSTRACT:"Aik2" OR TITLE:"IPL1" OR ABSTRACT:"IPL1" OR TITLE:"AurB" OR ABSTRACT:"AurB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AURKB, not a curated reading list.
Shares BUB1, Checkpoint (two meanings), CIViC.
Shares MPS1 (TTK), Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC, Head and neck squamous cell carcinoma.
Shares Checkpoint (two meanings), CIViC.
Shares BUB1, MPS1 (TTK), Checkpoint (two meanings).