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CEACAM1 (Cell adhesion molecule CEACAM1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Hepatocellular carcinoma.
Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors.
CIViC holds 3 clinical evidence items and 0 assertions across 2 variants.
In plain words · CEACAM1 (Cell adhesion molecule CEACAM1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Hepatocellular carcinoma.
CEACAM1 (Cell adhesion molecule CEACAM1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Hepatocellular carcinoma.
Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis.
No product in this corpus aims at CEACAM1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CEACAM1: RNA tissue enhanced (intestine 231 nTPM); blood lineage lineage enriched (granulocytes 44 nTPM); high antibody staining in 3 normal tissues; highest cancer staining colorectal cancer (1 of 10 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Colorectal cancer, Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas CEACAM1 tissue; Open Targets ENSG00000079385 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Hinoda et al, Proc. Natl. Acad. Sci. U.S.A, 1988, "Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen". Source.
Sources: HGNC HGNC:1814 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P13688 (protein name, function text, keywords and locations (REST API)); CIViC gene CEACAM1 (3 evidence items, 0 assertions, 2 variants; diseases: Colorectal Cancer, Hepatocellular Carcinoma (GraphQL API, CC0))
Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70. Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumour immunity by inhibiting T cell through its interaction with HAVCR2. Location: Cell membrane; Lateral cell membrane; Apical cell membrane; Basal cell membrane (UniProt). Locus 19q13.2 (HGNC).
RNA: tissue enhanced (intestine 231 nTPM), detected in many normal tissues. Blood: lineage enriched (granulocytes 44 nTPM).
Medium: Duodenum, Kidney, Small intestine.
RNA cancer enhanced: Colon Adenocarcinoma 123 pTPM, Rectum Adenocarcinoma 129 pTPM.
Medium only: liver cancer, melanoma, stomach cancer.
HPA CEACAM1 tissue · HPA CEACAM1 pathology · HPA protein class: CD markers
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CEACAM1" OR ABSTRACT:"CEACAM1" OR TITLE:"CEA cell adhesion molecule 1" OR ABSTRACT:"CEA cell adhesion molecule 1" OR TITLE:"Cell adhesion molecule CEACAM1" OR ABSTRACT:"Cell adhesion molecule CEACAM1" OR TITLE:"BGP1" OR ABSTRACT:"BGP1" OR TITLE:"CD66a" OR ABSTRACT:"CD66a") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CEACAM1, not a curated reading list.
Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.