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PLK1 (Serine/threonine-protein kinase PLK1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognised by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · PLK1 (Serine/threonine-protein kinase PLK1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
PLK1 (Serine/threonine-protein kinase PLK1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis.
1 product aims at PLK1: small molecules. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Broadly expressed or essential: HPA lists PLK1 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA PLK1: RNA tissue enhanced (bone marrow 30 nTPM, lymphoid tissue 41 nTPM, testis 32 nTPM); blood lineage lineage enriched (T-cells 6 nTPM); high antibody staining in 1 normal tissue. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Brain and spinal cord tumours (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PLK1 tissue; Open Targets ENSG00000166851 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Lake R.J. et al, Mol. Cell. Biol, 1993, "Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase". Source.
Sources: HGNC HGNC:9077 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P53350 (protein name, function text, keywords and locations (REST API)); CIViC gene PLK1 (1 evidence items, 0 assertions, 1 variants; diseases: Glioblastoma (GraphQL API, CC0))
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognised by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Location: Nucleus; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 16p12.2 (HGNC).
RNA: tissue enhanced (bone marrow 30 nTPM, lymphoid tissue 41 nTPM, testis 32 nTPM), detected in many normal tissues. Blood: lineage enriched (T-cells 6 nTPM).
Medium: Adrenal gland, Appendix, Breast, Bronchus, Cervix, Colon, Duodenum, Esophagus.
No cancer stained high; medium in breast cancer, cervical cancer, endometrial cancer, glioma.
HPA PLK1 tissue · HPA PLK1 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Onvansertib is an oral serine/threonine kinase inhibitor from Cardiff Oncology, in registered phase 2 trials for colorectal cancer.
Query for this target: (TITLE:"PLK1" OR ABSTRACT:"PLK1" OR TITLE:"polo like kinase 1" OR ABSTRACT:"polo like kinase 1" OR TITLE:"Serine/threonine-protein kinase PLK1" OR ABSTRACT:"Serine/threonine-protein kinase PLK1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLK1, not a curated reading list.
Shares BUB1, Checkpoint (two meanings), CIViC.
Shares BUB1, Mitosis & the spindle assembly checkpoint, Checkpoint (two meanings).
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Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.
Shares Checkpoint (two meanings), CIViC.