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CDK9 (Cyclin-dependent kinase 9) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Oesophageal cancer and Neuroblastoma.
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form.
CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Dinaciclib, Alvocidib and CAN508.
In plain words · CDK9 (Cyclin-dependent kinase 9) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Oesophageal cancer and Neuroblastoma.
CDK9 (Cyclin-dependent kinase 9) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Oesophageal cancer and Neuroblastoma.
Protein kinase involved in the regulation of transcription.
No product in this corpus aims at CDK9 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Broadly expressed or essential: HPA lists CDK9 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA CDK9: RNA low tissue specificity; high antibody staining in 44 normal tissues; highest cancer staining lymphoma (12 of 12 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma, Oesophageal cancer, Childhood cancers (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas CDK9 tissue; Open Targets ENSG00000136807 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Grana et al, Proc. Natl. Acad. Sci. U.S.A, 1994, "PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro". Source.
Sources: HGNC HGNC:1780 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P50750 (protein name, function text, keywords and locations (REST API)); CIViC gene CDK9 (3 evidence items, 0 assertions, 1 variants; diseases: Neuroblastoma, Hepatocellular Carcinoma, Oesophageal Cancer (GraphQL API, CC0))
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signalling). Location: Nucleus; Cytoplasm; Nucleus, PML body (UniProt). Locus 9q34.11 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Smooth muscle.
HPA CDK9 tissue · HPA CDK9 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CDK9" OR ABSTRACT:"CDK9" OR TITLE:"cyclin dependent kinase 9" OR ABSTRACT:"cyclin dependent kinase 9" OR TITLE:"Cyclin-dependent kinase 9" OR ABSTRACT:"Cyclin-dependent kinase 9" OR TITLE:"PITALRE" OR ABSTRACT:"PITALRE" OR TITLE:"C-2k" OR ABSTRACT:"C-2k" OR TITLE:"CDC2L4" OR ABSTRACT:"CDC2L4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDK9, not a curated reading list.
Shares Neuroblastoma (paediatric), CIViC.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma.
Shares MYC, Oesophageal cancer, CIViC.
Shares Neuroblastoma (paediatric), CIViC.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma.
Shares Transcriptional machinery & addiction, Oesophageal cancer, Hepatocellular carcinoma, CIViC.