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PCNA (DNA sliding clamp PCNA) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroblastoma.
Confers DNA tethering and processivity to DNA polymerases and other proteins. Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · PCNA (DNA sliding clamp PCNA) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroblastoma.
PCNA (DNA sliding clamp PCNA) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Neuroblastoma.
Confers DNA tethering and processivity to DNA polymerases and other proteins.
No product in this corpus aims at PCNA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists PCNA among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA PCNA: RNA tissue enhanced (bone marrow 362 nTPM); high antibody staining in 7 normal tissues; highest cancer staining cervical cancer (11 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Childhood cancers (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas PCNA tissue; Open Targets ENSG00000132646 associations
First described 1987. Earliest sequence paper UniProt cites for the protein: Almendral J.M. et al, Proc. Natl. Acad. Sci. U.S.A, 1987, "Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins". Source.
Sources: HGNC HGNC:8729 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P12004 (protein name, function text, keywords and locations (REST API)); CIViC gene PCNA (1 evidence items, 0 assertions, 1 variants; diseases: Neuroblastoma (GraphQL API, CC0))
Confers DNA tethering and processivity to DNA polymerases and other proteins. Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesise across the lesion. Location: Nucleus (UniProt). Locus 20p12.3 (HGNC).
RNA: tissue enhanced (bone marrow 362 nTPM), detected in all normal tissues.
Medium: Breast, Cervix, Duodenum, Endometrium, Epididymis, Esophagus, Fallopian tube, Gallbladder.
Medium only: prostate cancer, thyroid cancer.
HPA PCNA tissue · HPA PCNA pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PCNA" OR ABSTRACT:"PCNA" OR TITLE:"proliferating cell nuclear antigen" OR ABSTRACT:"proliferating cell nuclear antigen" OR TITLE:"DNA sliding clamp PCNA" OR ABSTRACT:"DNA sliding clamp PCNA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PCNA, not a curated reading list.
Shares Neuroblastoma (paediatric), CIViC.
Shares Neuroblastoma (paediatric), CIViC.
Shares Neuroblastoma (paediatric), CIViC.
Shares Neuroblastoma (paediatric), CIViC.