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FBLN2 (Fibulin-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Bladder & urothelial cancer, Hepatocellular carcinoma and 4 more.
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.
IntOGen calls it a driver in 8 cohorts (2 activating, 5 loss-of-function), covering Bladder Urothelial Carcinoma, Cholangiocarcinoma, Hepatocellular Carcinoma, Head and Neck Squamous Cell Carcinoma, Neuroblastoma, Pancreatic Adenocarcinoma and others.
In plain words · FBLN2 (Fibulin-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Bladder & urothelial cancer, Hepatocellular carcinoma and 4 more.
FBLN2 (Fibulin-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Bladder & urothelial cancer, Hepatocellular carcinoma and 4 more.
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.
No product in this corpus aims at FBLN2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1994. Earliest sequence paper UniProt cites for the protein: Zhang R.-Z. et al, Genomics, 1994, "Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes". Source.
Sources: HGNC HGNC:3601 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P98095 (protein name, function text, keywords and locations (REST API)); IntOGen FBLN2 (driver in 8 cohorts (Act 2, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 3p25.1 (HGNC).
Query for this target: (TITLE:"FBLN2" OR ABSTRACT:"FBLN2" OR TITLE:"fibulin 2" OR ABSTRACT:"fibulin 2" OR TITLE:"Fibulin-2" OR ABSTRACT:"Fibulin-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FBLN2, not a curated reading list.
Shares Neuroblastoma (paediatric), IntOGen, Pancreatic ductal adenocarcinoma, Prostate cancer.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma, IntOGen.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma, IntOGen.
Shares Neuroblastoma (paediatric), Bladder & urothelial cancer, IntOGen, Pancreatic ductal adenocarcinoma.
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), IntOGen, Pancreatic ductal adenocarcinoma.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma.