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BCORL1 (BCL-6 corepressor-like protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Pancreatic ductal adenocarcinoma, Skin cancer and 4 more.
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.81, animal model 0.40, genetic association 0.00, somatic mutation 0.90). IntOGen calls it a driver in 6 cohorts (0 activating, 6 loss-of-function), covering Acute Myeloid Leukaemia, Colorectal Adenocarcinoma, High-Grade Glioma, NOS, Neuroblastoma, Pancreatic Adenocarcinoma.
In plain words · BCORL1 (BCL-6 corepressor-like protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Pancreatic ductal adenocarcinoma, Skin cancer and 4 more.
BCORL1 (BCL-6 corepressor-like protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Pancreatic ductal adenocarcinoma, Skin cancer and 4 more.
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6.
No product in this corpus aims at BCORL1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1999. Earliest sequence paper UniProt cites for the protein: Rhodes, 1999. Source.
Sources: HGNC HGNC:25657 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5H9F3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000085185 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: colorectal cancer 0.60, melanoma 0.52, skin cancer 0.55, breast cancer 0.54 (GraphQL API, CC0)); IntOGen BCORL1 (driver in 6 cohorts (Act 0, LoF 6); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Location: Nucleus (UniProt). Locus Xq26.1 (HGNC).
Query for this target: (TITLE:"BCORL1" OR ABSTRACT:"BCORL1" OR TITLE:"BCL6 corepressor like 1" OR ABSTRACT:"BCL6 corepressor like 1" OR TITLE:"BCL-6 corepressor-like protein 1" OR ABSTRACT:"BCL-6 corepressor-like protein 1" OR TITLE:"FLJ11362" OR ABSTRACT:"FLJ11362" OR TITLE:"BCoR-L1" OR ABSTRACT:"BCoR-L1" OR TITLE:"CXorf10" OR ABSTRACT:"CXorf10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BCORL1, not a curated reading list.
Shares Neuroblastoma (paediatric), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Neuroblastoma (paediatric), Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Neuroblastoma (paediatric), IntOGen, Open Targets Platform, Pancreatic ductal adenocarcinoma.
Shares Neuroblastoma (paediatric), IntOGen, Breast cancer (all types).
Shares Neuroblastoma (paediatric), Acute myeloid leukaemia, IntOGen, Pancreatic ductal adenocarcinoma.
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), IntOGen, Pancreatic ductal adenocarcinoma.