Loading
PHOX2B (Paired mesoderm homeobox protein 2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer, Lung cancer and 2 more.
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.62, animal model 0.55, genetic association 0.02, somatic mutation 0.97).
In plain words · PHOX2B (Paired mesoderm homeobox protein 2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer, Lung cancer and 2 more.
PHOX2B (Paired mesoderm homeobox protein 2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer, Lung cancer and 2 more.
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates.
No product in this corpus aims at PHOX2B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Yokoyama et al, DNA Res, 1996, "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". Source.
Sources: HGNC HGNC:9143 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99453 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000109132 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: colorectal cancer 0.53, melanoma 0.57, neuroblastoma 0.63, skin cancer 0.56, lung cancer 0.52 (GraphQL API, CC0))
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element. Location: Nucleus (UniProt). Locus 4p13 (HGNC).
Query for this target: (TITLE:"PHOX2B" OR ABSTRACT:"PHOX2B" OR TITLE:"paired like homeobox 2B" OR ABSTRACT:"paired like homeobox 2B" OR TITLE:"Paired mesoderm homeobox protein 2B" OR ABSTRACT:"Paired mesoderm homeobox protein 2B" OR TITLE:"NBPhox" OR ABSTRACT:"NBPhox" OR TITLE:"PMX2B" OR ABSTRACT:"PMX2B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PHOX2B, not a curated reading list.
Shares Neuroblastoma (paediatric), Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Neuroblastoma (paediatric), Skin cancer (all types), Open Targets Platform.
Shares Neuroblastoma (paediatric), Lung cancer (all types), Open Targets Platform.
Shares Neuroblastoma (paediatric), Melanoma, Colorectal cancer.
Shares Neuroblastoma (paediatric), Melanoma.
Shares Neuroblastoma (paediatric), Skin cancer (all types), Lung cancer (all types), Colorectal cancer.